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Stem cells and regeneration

regeneratoinSome human tissues can undergo limited repair after injury, for example during wound healing in skin, and the liver can regenerate whole lobes. However, in general, the regeneration capacity of mammals is very limited compared with vertebrates such as fish and salamanders that can re-grow entire appendages. We would like to know how this extensive regeneration occurs and whether the principles can be applied to humans to make injury repair more efficient. After amputation of a fin, cells in the stump proliferate and give rise to a population of undifferentiated stem cells called the blastema. Scientists are studying the properties of blastema cells and how they differentiate in an orderly way to form a complete appendage of the same size and shape as the one that was lost.

Nelson Chao, M.D.
Professor of Medicine and Immunology
Department of Medicine
Division of Medical Oncology and Transplantation
Box 3961, DUMC, Durham, NC  27701
Phone: 919-668-1011
E-mail: chao0002@mc.duke.edu

John Chute, M.D.
Associate Professor
Department of Medicine
Division of Cellular Therapy Division
Box 3961, DUMC, Durham, NC  27710
Phone: 919-668-1011
E-mail: john.chute@duke.edu

Don Fox, Ph.D.
Pharmacology & Cancer Biology
Duke Box 3813
Durham, NC 27710
Phone: 919 613-8756(tel)
E-mail: don.fox@duke.edu

Ken Poss, Ph.D.
Assistant Professor
Department of Cell Biology
Box 3709, DUMC, Durham, NC  27710
Phone: 919-681-8457
E-mail: Kenneth.poss@duke.edu