Overview    |   Hematopoietic, Bone Marrow, Cord Blood    |   Mesenchymal    |   Cardiac    |   Neural    |   Epithelial    |   Pluripotential    |   Tissue Engineering    |   Genomics, Epigenetics, Noncoding RNAs    |   Regeneration    |   Cancer    |   Imaging   |   Germ Line Stem Cell

Mesenchymal stem cells

Many tissues in the body, for example, the connective tissue under the skin, cartilage, fat and blood vessels are made up of cells loosely known as “mesenchymal” cells. While many of the cells in these tissues are too specialized to self-renew, some can multiple extensively if the tissue is injured or placed in culture. Some of these mesenchymal cells behave like multipotent stem cells and can give rise to many different cell types. For example, cells from under the skin can give rise to muscle and cartilage. There is some evidence that these cells can also turn into nerve cells, but this is still controversial. Several Program members are studying mesenchymal cells derived from tissues like fat and cartilage. As described in the Stem cells and Bioengineering section, significant progress is being made in combining mesenchymal cells with artificial matrix material to make cartilage for grafting.

Anna Mae Diehl, M.D.
Department of Medicine aChiefnd , Division of Gastroenterology
Box 3256, DUMC, Durham, NC  27710
Phone: 919-684-4173
E-mail: annamae.diehl@duke.edu

Farshid Guilak, Ph.D.
Laszlo Ormandy Professor
Department of Surgery
Division of Orthopaedics
Box 3093, DUMC, Durham, NC  27710
Phone: 919-684-2521
E-mail: guilak@duke.edu

Matthew J. Hilton, PhD
Associate Professor of Orthopaedic Surgery
Duke University School of Medicine
Duke Musculoskeletal Research Center
Cellular, Developmental, and Genome Laboratories
450 Research Drive, LSRC B321C
DUMC Box 91009
Durham, NC 27710
Lab Phone: (919) 613-9753
Office Phone: (919) 613-9761
Email: matthew.hilton@dm.duke.edu

Joanne Kurtzberg, M.D.
Department of Pediatrics
Bone Marrow Transplant Program
Box 3350, DUMC, Durham, NC  27710
Phone: 919-668-1100
E-mail: kurtz001@mc.duke.edu

Dianne Little BVSc PhD MRCVS DACVS
Assistant Professor
Department of Orthopaedic Surgery
375 Medical Sciences Research Building
Box 3093
Duke University Medical Center
NC 27710
(919) 681-6867
Email: Dianne.Little@duke.edu